PUBLICATIONS
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2026
The Kaposi’s sarcoma-associated herpesvirus viral genome packaging accessory factor ORF68 forms cytoplasmic puncta dependent on the viral tyrosine kinase.
Sara Gelles-Watnick, Dawei Liu, Mayte Cerezo Matias, Jessica Liu, Giancarlo Ospina, Alicia Schäfer, Lilian Kabeche, Ileana Cristea, Allison Didychuk
biorxiv doi:10.64898/2026.02.23.707506
Conserved assembly architecture of the essential herpesvirus packaging accessory factor.
Elizabeth Bailey, Swapnil Devarkar, Renata Szczepaniak, Laura Meißner, Xinyu Chen, Chunxiang Wu, Sandra Weller, Yong Xiong, Allison Didychuk
biorxiv doi:10.64898/2026.01.22.701024
2025
Llacsahuanga-Allcca LE, Didychuk AL, Rodríguez-Vargas A, Glaunsinger BA.
Nucleic Acids Research doi: 10.1093/nar/gkaf1008.
The Kaposi's sarcoma-associated herpesvirus TBP mimic uses a noncanonical DNA-binding mode to promote viral late gene transcription.
2023
The viral packaging motor potentiates Kaposi's sarcoma-associated herpesvirus gene expression late in infection.
McCollum CO, Didychuk AL, Liu D, Murray-Nerger LA, Cristea IM, Glaunsinger BA.
Plos Pathogens doi: 10.1371/journal.ppat.1011163
DNA processing by the Kaposi's sarcoma-associated herpesvirus alkaline exonuclease SOX contributes to viral gene expression and infectious virion production.
Hartenian E, Mendez AS, Didychuk AL, Khosla S, Glaunsinger BA.
Nucleic Acids Research doi: 10.1093/nar/gkac1190
Better late than never: A unique strategy for late gene transcription in the beta- and gammaherpesviruses.
Dremel SA, Didychuk AL
Seminars in Cell & Developmental Biology doi: 10.1016/j.semcdb.2022.12.001
2022
The transition phase: preparing to launch a laboratory
McKinley KL*, Didychuk AL*, Nicholas DA, Termini CM.
Trends in Biochemical Sciences doi: 10.1016/j.tibs.2022.05.002; *co-first
A two-tiered functional screen identifies herpesviral transcriptional modifiers and their essential domains.
Morgens DW, Nandakumar D, Didychuk AL, Yang KJ, Glaunsinger BA.
Plos Pathogens doi: 10.1371/journal.ppat.1010236
2021
A pentameric protein ring with novel architecture is required for herpesviral packaging.
Didychuk AL, Gates SN, Gardner MR, Strong LM, Martin A, Glaunsinger BA.
eLife doi: 10.7554/eLife.62261
2020
The gammaherpesviral TATA-box-binding protein directly interacts with the CTD of host RNA Pol II to direct late gene transcription.
Castañeda AF*, Didychuk AL*, Louder RK, McCollum CO, Davis ZH, Nogales E, Glaunsinger BA.
Plos Pathogens doi: 10.1371/journal.ppat.1008843; *co-first
Conserved CxnC Motifs in Kaposi's Sarcoma-Associated Herpesvirus ORF66 Are Required for Viral Late Gene Expression and Are Essential for Its Interaction with ORF34.
Didychuk AL, Castañeda AF, Kushnir LO, Huang CJ, Glaunsinger BA.
Journal of Virology doi: 10.1128/JVI.01299-19
2018
Architecture of the U6 snRNP reveals specific recognition of 3'-end processed U6 snRNA.
Montemayor EJ, Didychuk AL, Yake AD, Sidhu GK, Brow DA, Butcher SE.
Nature Communications doi: 10.1038/s41467-018-04145-4
The life of U6 small nuclear RNA, from cradle to grave.
Didychuk AL, Butcher SE, Brow DA.
RNA doi: 10.1261/rna.065136.117
2017
Usb1 controls U6 snRNP assembly through evolutionarily divergent cyclic phosphodiesterase activities.
Didychuk AL, Montemayor EJ, Carrocci TJ, DeLaitsch AT, Lucarelli SE, Westler WM, Brow DA, Hoskins AA, Butcher SE.
Nature Communications doi: 10.1038/s41467-017-00484-w
Structure and conformational plasticity of the U6 small nuclear ribonucleoprotein core.
Montemayor EJ, Didychuk AL, Liao H, Hu P, Brow DA, Butcher SE.
Acta Crystallographica Section D, Structural Biology doi: 10.1107/S2059798316018222
2016
A multi-step model for facilitated unwinding of the yeast U4/U6 RNA duplex.
Rodgers ML, Didychuk AL, Butcher SE, Brow DA, Hoskins AA.
Nucleic Acids Research doi: 10.1093/nar/gkw686
Structural requirements for protein-catalyzed annealing of U4 and U6 RNAs during di-snRNP assembly.
Didychuk AL, Montemayor EJ, Brow DA, Butcher SE.
Nucleic Acids Research doi: 10.1093/nar/gkv1374
Structural Analysis of Multi-Helical RNAs by NMR-SAXS/WAXS: Application to the U4/U6 di-snRNA.
Cornilescu G*, Didychuk AL*, Rodgers ML, Michael LA, Burke JE, Montemayor EJ, Hoskins AA, Butcher SE.
Journal of Molecular Biology doi: 10.1016/j.jmb.2015.11.026; *co-first
2013
Structure of Pisum sativum Rubisco with bound ribulose 1,5-bisphosphate.
Loewen PC, Didychuk AL, Switala J, Perez-Luque R, Fita I, Loewen MC.
Acta Crystallographica Section F doi: 10.1107/S1744309112047549